Human IL-36G
IL-36G binds to the IL1RL2/IL-36R receptor, activating NF-kappa-B and MAPK signaling pathways, similar to the IL-1 system. It is involved in local inflammatory responses, particularly in epithelial tissues.
IL-36G enhances skin inflammatory responses by acting on keratinocytes and dendritic cells, promoting tissue infiltration, cell maturation, and proliferation. It induces chemokines (e.g., CCL3, CCL4, CCL5) and pro-inflammatory factors like TNF-alpha and S100A7/psoriasin. Additionally, IL-36G activates lung fibroblasts, increasing IL-8 and CCL20 expression, and may play a role in the innate immune response to fungal pathogens like Aspergillus fumigatus.
TU-1
hERP29 Proximal Promoter, a Synthetic Splice, and a portion of the hACTB gene.
A portion of the hUCP2 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hS100A11 gene.
A portion of the hEIF-4A1 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hADAM9 gene.
A portion of the hPCNA Proximal Promoter, a Synthetic Splice, and a terminal portion of the hCOL5A1 gene.
A portion of the Murine Cytohesin-1 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hACTN1 gene.
A portion of the Mus E2A Proximal Promoter, a Synthetic Splice, and a terminal portion of the hKDELR3 gene.
A portion of the hPNP Proximal Promoter, a Synthetic Splice, and a terminal portion of the hANPEP gene.
A portion of the bMHC Proximal Promoter, a Synthetic Splice, and a terminal portion of the hCD58 gene
*NOTE: bMHC info (USPTO-US005441889A)
hERP29 Proximal Promoter, a Synthetic Splice, and a portion of the hACTB gene.
A portion of the hUCP2 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hS100A11 gene.
A portion of the hEIF-4A1 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hADAM9 gene.
A portion of the hPCNA Proximal Promoter, a Synthetic Splice, and a terminal portion of the hCOL5A1 gene.
A portion of the Murine Cytohesin-1 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hACTN1 gene.
A portion of the Mus E2A Proximal Promoter, a Synthetic Splice, and a terminal portion of the hKDELR3 gene.
A portion of the hPNP Proximal Promoter, a Synthetic Splice, and a terminal portion of the hANPEP gene.
A portion of the bMHC Proximal Promoter, a Synthetic Splice, and a terminal portion of the hCD58 gene
*NOTE: bMHC info (USPTO-US005441889A)