Mouse IL-27A

IL27A is part of the heterodimeric cytokine IL-27, formed with EBI3. It plays a crucial role in regulating immune responses, with both pro-inflammatory and anti-inflammatory properties.

Key Roles:

  • T-Cell Differentiation: IL27A promotes the differentiation of naive CD4 T-cells into type 1 effector cells (TH1), while suppressing TH2 and TH17 cell development.
  • Cytokine Production: It synergizes with IL-12 to enhance IFN-gamma production, driving a robust TH1 response.
  • Signaling Pathways: IL27A activates several signaling pathways through its receptor WSX-1/TCCR, involving STAT1, STAT3, STAT4, and STAT5, as well as p38 MAPK.
  • Inhibition of Pro-inflammatory Cytokines: IL27A suppresses the production of pro-inflammatory cytokines such as IL-2, IL-4, and IL-6, and promotes the expression of suppressors of cytokine signaling (SOCS1 and SOCS3).
  • Antitumor Activity: It has been shown to exert anti-tumor effects and promote the production of anti-angiogenic chemokines, aiding in the regulation of tumor growth.

IL27A is vital for balancing immune responses and maintaining homeostasis, particularly in the context of infections and inflammatory diseases.

License Type
Product number: SW10112.1

TU-1

hERP29 Proximal Promoter, a Synthetic Splice, and a portion of the hACTB gene.

A portion of the hUCP2 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hS100A11 gene.

A portion of the hEIF-4A1 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hADAM9 gene.

A portion of the hPCNA Proximal Promoter, a Synthetic Splice, and a terminal portion of the hCOL5A1 gene.

A portion of the Murine Cytohesin-1 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hACTN1 gene.

A portion of the Mus E2A Proximal Promoter, a Synthetic Splice, and a terminal portion of the hKDELR3 gene.

A portion of the hPNP Proximal Promoter, a Synthetic Splice, and a terminal portion of the hANPEP gene. 

A portion of the bMHC Proximal Promoter, a Synthetic Splice, and a terminal portion of the hCD58 gene

*NOTE: bMHC info (USPTO-US005441889A)

hERP29 Proximal Promoter, a Synthetic Splice, and a portion of the hACTB gene.

A portion of the hUCP2 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hS100A11 gene.

A portion of the hEIF-4A1 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hADAM9 gene.

A portion of the hPCNA Proximal Promoter, a Synthetic Splice, and a terminal portion of the hCOL5A1 gene.

A portion of the Murine Cytohesin-1 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hACTN1 gene.

A portion of the Mus E2A Proximal Promoter, a Synthetic Splice, and a terminal portion of the hKDELR3 gene.

A portion of the hPNP Proximal Promoter, a Synthetic Splice, and a terminal portion of the hANPEP gene. 

A portion of the bMHC Proximal Promoter, a Synthetic Splice, and a terminal portion of the hCD58 gene

*NOTE: bMHC info (USPTO-US005441889A)