Mouse IL-34

IL34 is a cytokine primarily involved in the regulation of monocytes, macrophages, and osteoclasts, playing a significant role in immune responses and inflammatory processes.

Key Roles:

  • Monocyte and Macrophage Regulation: IL34 promotes the proliferation, survival, and differentiation of monocytes and macrophages, enhancing their role in innate immunity.
  • Pro-inflammatory Chemokine Release: It stimulates the release of pro-inflammatory chemokines, contributing to the inflammatory response.
  • Osteoclast Proliferation and Differentiation: IL34 is crucial in regulating osteoclast proliferation and differentiation, thereby influencing bone resorption processes.
  • Signaling Pathways: IL34 signals through the CSF1 receptor (CSF1R), leading to the activation of downstream effectors, including the phosphorylation of MAPK1/ERK2 and MAPK3/ERK1, which are involved in various cellular processes.

IL34 plays a vital role in both immune system regulation and bone metabolism, linking inflammation with osteoclast function.

License Type
Product number: SW10116.1

TU-1

hERP29 Proximal Promoter, a Synthetic Splice, and a portion of the hACTB gene.

A portion of the hUCP2 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hS100A11 gene.

A portion of the hEIF-4A1 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hADAM9 gene.

A portion of the hPCNA Proximal Promoter, a Synthetic Splice, and a terminal portion of the hCOL5A1 gene.

A portion of the Murine Cytohesin-1 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hACTN1 gene.

A portion of the Mus E2A Proximal Promoter, a Synthetic Splice, and a terminal portion of the hKDELR3 gene.

A portion of the hPNP Proximal Promoter, a Synthetic Splice, and a terminal portion of the hANPEP gene. 

A portion of the bMHC Proximal Promoter, a Synthetic Splice, and a terminal portion of the hCD58 gene

*NOTE: bMHC info (USPTO-US005441889A)

hERP29 Proximal Promoter, a Synthetic Splice, and a portion of the hACTB gene.

A portion of the hUCP2 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hS100A11 gene.

A portion of the hEIF-4A1 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hADAM9 gene.

A portion of the hPCNA Proximal Promoter, a Synthetic Splice, and a terminal portion of the hCOL5A1 gene.

A portion of the Murine Cytohesin-1 Proximal Promoter, a Synthetic Splice, and a terminal portion of the hACTN1 gene.

A portion of the Mus E2A Proximal Promoter, a Synthetic Splice, and a terminal portion of the hKDELR3 gene.

A portion of the hPNP Proximal Promoter, a Synthetic Splice, and a terminal portion of the hANPEP gene. 

A portion of the bMHC Proximal Promoter, a Synthetic Splice, and a terminal portion of the hCD58 gene

*NOTE: bMHC info (USPTO-US005441889A)