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Interleukin 11 (IL-11), encoded by the IL11 gene, is a cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells, enhancing megakaryocyte maturation and increasing platelet production. It also promotes hepatocyte proliferation in response to liver damage. IL-11 exerts its effects by binding to a receptor complex formed by IL6ST and IL11RA, activating intracellular signaling pathways that lead to the phosphorylation of STAT3, with both 'classic' and 'trans-signaling' mechanisms contributing to its biological functions.