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Interleukin-1 beta (IL-1β), encoded by the IL1B gene, is a potent pro-inflammatory cytokine critical for immune response and inflammation. It is generated from its precursor through caspase 1 cleavage and plays a key role in various processes, including T-cell activation, neutrophil recruitment, and angiogenesis. Additionally, IL-1β acts as a sensor for bacterial infections, such as those caused by Streptococcus pyogenes, triggering inflammatory responses that help combat invasive pathogens.