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IL-22 is critical for modulating tissue responses during inflammation, aiding in the regeneration of epithelial cells to maintain barrier function after injury and preventing further tissue damage. Unlike many cytokines, IL-22 does not directly affect immune cells. It signals through a heterodimeric receptor composed of IL22RA1, found on non-immune cells, and IL10RB. This interaction activates JAK1 and TYK2 kinases, leading to STAT3 activation, which promotes cell survival and proliferation via the STAT3, ERK1/2, and PI3K/AKT pathways.