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IL-33 is a member of the IL-1 family that stimulates the production of T helper 2 (Th2)-associated cytokines, such as IL-4. It binds to the ST2 receptor (IL1RL1), predominantly expressed on Th2 cells, mast cells, and group 2 innate lymphocytes, activating NF-kappa-B and MAPK signaling pathways.