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Interleukin-5 (IL-5) is a homodimeric cytokine produced primarily by type-2 T helper cells and mast cells, playing a vital role in the survival, differentiation, and chemotaxis of eosinophils. It also stimulates activated and resting B-cells to promote immunoglobulin production and growth. IL-5 exerts its effects through a receptor composed of the IL5RA subunit and a common beta subunit, activating various kinases and propagating signals via the RAS-MAPK and JAK-STAT5 pathways.