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Interleukin-6 (IL-6), encoded by the IL6 gene, functions as both a pro-inflammatory cytokine and an anti-inflammatory myokine, playing diverse roles in immunity, tissue regeneration, and metabolism. It binds to IL6R, forming a complex with IL6ST/gp130 to initiate various signaling pathways, including 'classic signaling' and 'trans-signaling,' which are crucial during infection and tissue injury. IL-6 is a key inducer of the acute phase response, essential for B cell differentiation, T cell subset development, and bone homeostasis, while also influencing metabolic processes and iron metabolism, particularly during inflammation.