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Interleukin-8 (IL-8 or CXCL8) is a chemokine produced by macrophages and various cell types, including epithelial and endothelial cells, that plays a key role in mediating the inflammatory response. It acts as a chemotactic factor, attracting neutrophils, basophils, and T-cells to sites of infection to help clear pathogens and protect the host. Upon release in response to inflammatory stimuli, IL-8 binds to the G-protein-coupled receptors CXCR1 and CXCR2 on immune cells, triggering downstream signaling pathways such as PI3K and MAPK, which are crucial for neutrophil activation and recruitment.