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A cytokine crucial for modulating tissue responses during inflammation and for regenerating epithelial cells, maintaining barrier function after injury. Unlike most cytokines, IL-22 primarily affects non-immune cells and has no direct impact on immune cells. It signals through a receptor composed of IL22RA1 and IL10RB, activating JAK1 and TYK2, which leads to STAT3 activation. This cascade promotes cell survival and proliferation through multiple pathways, including ERK1/2 and PI3K/AKT, and enhances epithelial cell spreading.