$65.00 - $125.00
A multifunctional cytokine primarily produced by T-cells, IL-24 plays a vital role in immune regulation, tissue homeostasis, host defense, and oncogenesis. It exhibits antiviral properties and induces the type I interferon response during influenza infections. IL-24 signals through receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1, activating the JAK1-STAT3 and MAPK pathways, which promote the secretion of pro-inflammatory mediators like IL-8 and MMP1. Additionally, it helps maintain endoplasmic reticulum homeostasis and serves as a quality control mechanism for the ubiquitin-proteasome system by activating PKR/EIF2AK2 in response to proteasome dysfunction.